The eukaryote chromosome, a two-state system with interconversion by a volume phase transition | Science
The formation of metaphase chromosomes requires the activity of condensins, DNA translocases that reduce chromosomal length through the process of loop extrusion. Reduction of length, however, does not account for the increase in density of chromatin in ...
A cross-organ single-cell analysis of hypertension | Science
Hypertension is a leading cause of disease burden and mortality. Here, we present a single-cell analysis of hypertension and end-organ damage across six organs and tissues in angiotensin II–treated mice, Dahl salt–sensitive rats, and spontaneously ...
Chemovaccination with a late-liver-stage antimalarial induces durable immunity against malaria | Science
Plasmodium falciparum sporozoite vaccines, in which parasites are attenuated at the liver stage, provide high efficacy but require complex manufacture and intravenous administration of high sporozoite doses. We found that a single low-dose P. berghei ...
Artificial hibernation reveals synaptic engram architecture associated with memory retention | Science
Memories leave lasting physical changes at the synaptic level. Although stable, larger spines are thought to support memory, the high turnover of dendritic spines and the drifting of neuronal representations after memory formation suggest alternative ...
A thalamocortical circuit encoding deviations from sensory history | Science
Prior expectations guide attention and support perceptual filtering during decision-making. In mice performing a visual discrimination task, choices depended on trial-by-trial differences between consecutive stimuli (|ΔDir|). We hypothesized that ...
How to make your science business succeed when you’re a female founder
Nature, Published online: 13 August 2026; doi:10.1038/d41586-026-01904-y Sexist assumptions and a male-dominated culture can make it […]
Author Correction: Cretaceous bird from Brazil informs the evolution of the avian skull and brain
Nature, Published online: 13 August 2026; doi:10.1038/s41586-026-10960-3 Author Correction: Cretaceous bird from Brazil informs the evolution […]
Author Correction: Structural mechanism of cGAS inhibition by the nucleosome
Nature, Published online: 13 August 2026; doi:10.1038/s41586-026-10959-w Author Correction: Structural mechanism of cGAS inhibition by the […]