SGLT2 inhibitors activate pantothenate kinase in the human heart

27 August, 2026 - Author: kmcjana

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce mortality in heart failure, but their pharmacological target remains unclear. In this study, we showed that SGLT2i directly activate pantothenate kinase 1 (PANK1), the rate-limiting enzyme in …

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SGLT2 inhibitors activate pantothenate kinase in the human heart | Science

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