Creative hobbies could slow brain ageing at the molecular level
Nature, Published online: 03 October 2025; doi:10.1038/d41586-025-03197-z To keep the mind young, dance the tango.
Weaponizing uncertainty in science and in public health puts people in harm’s way
Nature, Published online: 03 October 2025; doi:10.1038/d41586-025-03167-5 Those who cite scientific studies to support policies should […]
These science prizes want to rival the Nobels: how do they compare?
Nature, Published online: 03 October 2025; doi:10.1038/d41586-025-03118-0 Being named as a Nobel laureate is the ultimate […]
New radioactive isotope therapies promise more targeted attacks on cancer
Recent clinical successes, and profits, have prompted a rush among pharma companies to try new isotopes and targeting strategies
Localized glutamine leakage drives the spatial structure of root microbial colonization | Science
Plant roots release exudates to encourage microbiome assembly, which influences the function and stress resilience of plants. How specific exudates drive spatial colonization patterns remains largely unknown. In this study, we demonstrate that endodermal ...
GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling | Science
During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stresses. GCN2 activation has been linked to its ...
Intercellular communication in the brain through a dendritic nanotubular network | Science
Intercellular nanotubular networks mediate material exchange, but their existence in neurons remains to be explored in detail. We identified long, thin dendritic filopodia forming direct dendrite–dendrite nanotubes (DNTs) in mammalian cortex. Super-...
A comprehensive genetic catalog of human double-strand break repair | Science
The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) within a genome-wide knockout library, we present a ...
ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes | Science
Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remodelers, ACF and RSC, using chromatin condensates and ...
Lithium-ion intercalation by coupled ion-electron transfer | Science
The underlying reaction mechanism in lithium-ion batteries remains poorly understood. We provide experimental and theoretical evidence that lithium intercalation occurs by coupled ion-electron transfer, where ion transfer across the electrode-electrolyte ...