GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling | Science
During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stresses. GCN2 activation has been linked to its ...
Persistent eastern equatorial Pacific Ocean upwelling since the warm Pliocene | Science
Upwelling generates a nutrient-rich “cold tongue” in the eastern equatorial Pacific Ocean (EEP), with impacts on global climate, oceanic biological productivity, and the carbon cycle. The cold tongue was reduced during the Pliocene Epoch, a feature ...
Intercellular communication in the brain through a dendritic nanotubular network | Science
Intercellular nanotubular networks mediate material exchange, but their existence in neurons remains to be explored in detail. We identified long, thin dendritic filopodia forming direct dendrite–dendrite nanotubes (DNTs) in mammalian cortex. Super-...
A comprehensive genetic catalog of human double-strand break repair | Science
The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) within a genome-wide knockout library, we present a ...
ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes | Science
Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remodelers, ACF and RSC, using chromatin condensates and ...
Lithium-ion intercalation by coupled ion-electron transfer | Science
The underlying reaction mechanism in lithium-ion batteries remains poorly understood. We provide experimental and theoretical evidence that lithium intercalation occurs by coupled ion-electron transfer, where ion transfer across the electrode-electrolyte ...
The paradox of AI accelerationism and the promise of public interest AI | Science
Over the past 3 years, the idea that artificial intelligence (AI) development should be accelerated without restraint to drive radical societal change—a phenomenon known as AI accelerationism—has gained traction in Silicon Valley. The most prominent form ...
Author Correction: EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells
Nature, Published online: 02 October 2025; doi:10.1038/s41586-025-09691-8 Author Correction: EBI2 augments Tfh cell fate by promoting […]
Publisher Correction: Multimodal cell maps as a foundation for structural and functional genomics
Nature, Published online: 02 October 2025; doi:10.1038/s41586-025-09648-x Publisher Correction: Multimodal cell maps as a foundation for […]
Public trust in science has declined since COVID — virologists need to unite around safety standards
Nature, Published online: 29 September 2025; doi:10.1038/d41586-025-03151-z Creating international viral biosafety guidelines are key to clearing […]