Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis

27 August, 2026 - Author: kmcjana

Suppressor transfer RNAs (sup-tRNAs) can rescue disease-causing nonsense mutations by promoting readthrough of premature termination codons (PTCs). Their clinical translation is limited by suboptimal activity and inefficient in vivo delivery. In this …

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Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis | Science

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