Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis | Science
Suppressor transfer RNAs (sup-tRNAs) can rescue disease-causing nonsense mutations by promoting readthrough of premature termination codons (PTCs). Their clinical translation is limited by suboptimal activity and inefficient in vivo delivery. In this ...
Autism mutations rewire protein interaction networks to drive neurodevelopmental pathology | Science
Systematic mapping of protein-protein interaction (PPI) networks and determining how causal mutations rewire them in autism spectrum disorder (ASD) provide a powerful framework for uncovering disease mechanisms and therapeutic opportunities. Using ...
Science is based on assumptions. Philosophy can make sure they’re the right ones. | Science
When I was a postdoctoral researcher, I spent several years teaching at an interdisciplinary research institute in Vienna, Austria. There, my main course sought to train master’s students—mostly biologists and veterinarians—to write a philosophical reflection on some aspect of the comparative cognition studies they were running.
SGLT2 inhibitors activate pantothenate kinase in the human heart | Science
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce mortality in heart failure, but their pharmacological target remains unclear. In this study, we showed that SGLT2i directly activate pantothenate kinase 1 (PANK1), the rate-limiting enzyme in ...
Hypervision: An on-chip hyperspectral microsystem for online video-rate computational imaging | Science
In this work, we tackled the long-standing challenge of the massive computation for hyperspectral imaging that is required to reconstruct and process large-volume spatial-spectral data cubes. Specifically, we designed a hardware accelerator, fabricated ...
High-efficiency, long-lived lead-free perovskite light-emitting diodes | Science
Tin halide perovskite light-emitting diodes (PeLEDs) offer promise due to their solution processability and low toxicity, yet low efficiency and poor stability hinder practical use. We found that electroluminescence failure in CsSnI3 is primarily driven ...
In Other Journals | Science
Editors’ selections from the current scientific literature
Glacier collapse caused Nepal’s deadly flash flood — a sign of things to come?
Nature, Published online: 27 August 2026; doi:10.1038/d41586-026-02716-w Global warming is making high-altitude regions unstable, and could […]
Women face bans on research underground — here’s how to modernize the system
Nature, Published online: 27 August 2026; doi:10.1038/d41586-026-02679-y In many countries, female engineers are barred from entering […]
The Roman telescope is about to take planet-hunting to the next level
Nature, Published online: 27 August 2026; doi:10.1038/d41586-026-02662-7 NASA’s Nancy Grace Roman Space Telescope, set to launch […]